Molecular medicine – faculty
Our research group aims to understand the roles that mammalian enzymes play in physiological and pathological processes and to use this knowledge to identify novel therapeutic targets for the treatment of human disease. New innovations in technology 2014 To achieve these goals, we develop and apply new technologies that bridge the fields of chemistry and biology, ascribing to the philosophy that the most significant biomedical problems require creative multidisciplinary approaches for their solution. Uva new innovations Our technological innovations address fundamental challenges in systems biology that are beyond the scope of contemporary methods.
New innovations website For instance, enzymes are tightly regulated by post-translational events in vivo, meaning that their activity may not correlate with expression as measured by standard genomic and proteomic approaches. New innovations in science Considering that it is an enzyme’s activity, rather than abundance that ultimately dictates its role in cell physiology and pathology, we have introduced a set of proteomic technologies that directly measures this parameter. New innovations in technology These activity-based protein profiling (ABPP) methods exploit the power of chemistry to engender new tools and assays for the global analysis of enzyme activities. New and innovative business ideas in india The enzyme activity profiles generated by ABPP constitute unique molecular portraits of cells and tissues that illuminate how metabolic and signaling networks are regulated in vivo. New innovations suny downstate Additionally, by evaluating enzymes based on functional properties rather than mere abundance, ABPP acquires high-content proteomic information that is enriched in novel markers and targets for the diagnosis and treatment of human disease.
We complement these efforts in technology development with focused studies on individual enzymes. New innovations in technology computers With particular interests in the nervous system and cancer, we select proteins, such as the endocannabinoid-degrading enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), for detailed investigation using a range of chemical, biochemical, genetic, and pharmacological techniques. New innovations in construction technology This multidisciplinary approach ensures that we generate all of the tools and models required to assign molecular, cellular, and physiological functions to enzymes and, as an important corollary, assess their suitability as therapeutic targets. New innovation technologies dubai Notably, these basic discovery projects both benefit from and provide a fertile testing ground for our technological innovations. New innovations partners Thus, through the integration of two complementary research programs, one dedicated to methods development for functional proteomics, and the other to the characterization of key signaling enzymes, our group achieves a unique balance that cultivates the creation and rapid implementation of cutting-edge technologies that address unmet needs in experimental biology. New innovations for 2014 Education
Weerapana E*, Wang C*, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF. New innovations in electrical technology (2010) Quantitative reactivity profiling predicts functional cysteines in proteomes. New innovations sign in Nature. 468:790-5
Schlosburg JE*, Blankman JL*, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF. Partners new innovations (2010) Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Vanderbilt new innovations Nat Neurosci. 13(9):1113-9
Nomura DK, Long JZ, Niessen S, Hoover HS, Ng S, Cravatt BF. New innovations in computer technology 2013 (2010) Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis. Www new innovations Cell. 140(1):49-61
Bachovchin DA, Brown SJ, Rosen H, Cravatt BF. New technological innovations (2009) Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. New innovations in technology in 2015 Nat Biotechnol. 27(4):387-94.
Long JZ, Li W, Booker L, Burston JJ, Kinsey SH, Schlosburg JE, Pavon FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF. New technology innovations in business (2009) Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. New innovations log in Nat Chem Biol. 5(37):37-44.
Blankman JL, Simon GM, Cravatt BF. New technologies trends innovations and research (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. New innovations ttuhsc Chem Biol. 14(12):1347-1356.
Chiang KP, Niessen S, Saghatelian A, Cravatt BF. New innovations in technology 2016 (2006) An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. New innovations in computer technology 2014 Chem Biol. 13(10):1041-1050.
Sieber SA, Niessen S, Hoover HS, Cravatt BF. New innovations in software technology (2006) Proteomic profiling of metalloprotease activities withcocktails of active-site probes. List of new innovations Nat Chem Biol. 2(5):274-281
Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF (2005) Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. New innovations login Nat Biotechnol. 23(10):1303-1307.
Jessani N, Niessen S, Wei BQ, Nicolau M, Humphrey M, Ji Y, Han W, Noh DY, Yates JR 3rd, Jeffrey SS, CravattBF. New and innovative ideas for business (2005) A streamlined platform for high-content functional proteomics of primary human specimens. New inventions and innovations Nat Methods. 2(9):691-697.
Saghatelian A, Trauger SA, Want EJ, Hawkins EG, Siuzdak G, and Cravatt BF. New innovations in computer technology 2015 (2004) Assignment of endogenoussubstrates to enzymes by global metabolite profiling. New innovations in educational technology Biochemistry. 43(45):14332-14339
Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt BF. New innovations in healthcare technology (2004) Activity-based probes for the proteomic profiling of metalloproteases. New innovations residency Proc Natl Acad Sci USA. 101(27):10000-10005.
Speers AE, Adam GC, Cravatt BF. New innovations in mobile technology (2003) Activity-based protein profiling in vivo using a copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition. New innovations in banking technology J Am Chem Soc. 125(16):4686-4687.
Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF. New innovations residency login (2002) Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. New innovations 2014 Science. 298(5599):1793-1796.
Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. New innovations resident login (1996) Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. What is new innovations Nature 384(6604):83-87.
Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. New innovations and inventions (1995) Chemical characterization of a family of brain lipids that induce sleep. Best new innovations Science 268(5216):1506-1509. New innovations in packaging technology Links